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18,20,21 The different families of PRRs have distinct structural properties and respond to different PAMPs and DAMPs, but they share many similarities in the downstream signal transduction pathways

Meanwhile, we detected the HIF-1, a key protein in the mechanism of APAP-induced liver injury 35 and found that 5-HT could decrease the expression of HIF-1 by which 5-HT contributed to relieve of APAP-induced hepatotoxicity (Figure 8D and 8E)